HOW SAMe WORKS
Preliminary evidence suggests SAMe might stimulate joint cartilage growth and repair. SAMe might also protect against inflammatory cell damage by inhibiting the activity of TNF-alpha on synovial joint cells. SAMe is associated with increased serotonin turnover and elevated dopamine and norepinephrine levels, which helps to regulate mood. SAMe supplementation may also work by altering cellular membrane fluidity and increase the efficiency of brain receptors.